We report the identification, genomic structure, chromosomal localization,
and expression analysis of human frizzled-3 (FZD3), a 7-transmembrane recep
tor belonging to the frizzled family. The cDNA obtained from adult human br
ain shows 91% identity at the nucleotide level and 98% at the amino acid le
vel to mouse frizzled-3 (fzd3), The FZD3 locus is located on chromosome 8p2
1, spans 48 Kb and its coding sequence is distributed in 6 exons intercalat
ed by 5 introns, FZD3 is expressed in all analyzed human tissues, with quan
titatively higher expression in the CNS and in urogenital structures. (C) 2
000 Academic Press.