We isolated cDNA encoding a novel FGF (210 amino acids) from mouse embryos.
As this is the 21st documented FGF, we tentatively term it FGF-21. FGF-21
has a hydrophobic amino terminus (similar to 30 amino acids), which is a ty
pical signal sequence, and appears to be a secreted protein. The expression
of FGF-21 mRNA in mouse adult tissues was examined by Northern blotting an
alysis. FGF-21 mRNA was most abundantly expressed in the liver, and also ex
pressed in the thymus at lower levels. We also isolated human cDNA encoding
FGF-21 (209 amino acids). Human FGF-21 is highly identical (similar to 75%
amino acid identity) to mouse FGF-21. Among human FGF family members, FGF-
21 is most similar (similar to 35% amino acid identity) to FGF-19. (C) 2000
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