Extraordinarily high density of unrelated genes showing overlapping and intraintronic transcription units

Authors
Misener, SR Walker, VK
Citation
Sr. Misener et Vk. Walker, Extraordinarily high density of unrelated genes showing overlapping and intraintronic transcription units, BBA-GENE ST, 1492(1), 2000, pp. 269-270
Citations number
7
Categorie Soggetti
Molecular Biology & Genetics
Journal title
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
ISSN journal
01674781 → ACNP
Volume
1492
Issue
1
Year of publication
2000
Pages
269 - 270
Database
ISI
SICI code
0167-4781(20000621)1492:1<269:EHDOUG>2.0.ZU;2-5
Abstract
The cloning of pyrroline 5-carboxylate reductase from Drosophila melanogast er was accomplished by cDNA complementation of an Escherichia coli proline auxotroph. The corresponding P5cr gene is tightly clustered with three othe r expressed coding regions. A bidirectional promoter, an overlapping 3'UTR and an intraintronic sequence may all be found in only 4.3 kb, making this the most densely clustered region of unrelated genes in any eukaryote. (C) 2000 Elsevier Science B.V. All rights reserved.