Non-effect of hexamethonium, a ganglionic blocker, on the response of ileal apolipoprotein A-IV mRNA following a massive small bowel resection in rats

An intravenous infusion of hexamethonium, a ganglionic blocker, did not aff ect the increase in the apolipoprotein A-IV mRNA level in the residual ileu m following a massive small bowel resection in unrestrained conscious rats. The result suggests that upregulation of the apolipoprotein A-IV gene in t he residual ileum is not mediated by a neural pathway, including the nicoti nic synapse route.