Regional difference of neuronal vulnerability in the murine hippocampus after transient forebrain ischemia

Authors
Yang, G Kitagawa, K Ohtsuki, T Kuwabara, K Mabuchi, T Yagita, Y Takazawa, K Tanaka, S Yanagihara, T Hori, M Matsumoto, M
Citation
G. Yang et al., Regional difference of neuronal vulnerability in the murine hippocampus after transient forebrain ischemia, BRAIN RES, 870(1-2), 2000, pp. 195-198
Citations number
17
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
870
Issue
1-2
Year of publication
2000
Pages
195 - 198
Database
ISI
SICI code
0006-8993(20000707)870:1-2<195:RDONVI>2.0.ZU;2-F
Abstract
We have investigated the regional difference of neuronal vulnerability with in the hippocampus in the C57BL/6 strain mice after forebrain ischemia. Bot h common carotid arteries of fifty mice were occluded for 12 min and the mo use brain was examined with cresyl violet staining. The CA4 sector was foun d to be the most vulnerable within the hippocampus. The CA2 and the medial CA1 sector was the 2nd and 3rd most vulnerable regions. However, The latera l part of the CA1 sector, CA3 sector and the dentate gyrus were resistant t o ischemic insult. (C) 2000 Elsevier Science B.V. All rights reserved.