Morphine and methadone have different effects on calcium channel currents in neuroblastoma cells

Authors
Yang, JC Shan, J Ng, KF Pang, P
Citation
Jc. Yang et al., Morphine and methadone have different effects on calcium channel currents in neuroblastoma cells, BRAIN RES, 870(1-2), 2000, pp. 199-203
Citations number
10
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
870
Issue
1-2
Year of publication
2000
Pages
199 - 203
Database
ISI
SICI code
0006-8993(20000707)870:1-2<199:MAMHDE>2.0.ZU;2-1
Abstract
Using patch-clamp technique, cellular calcium channel currents were studied on nine mouse neuroblastoma N1E115 cells. Both morphine and methadone decr eased the T-type calcium currents in dose-dependent fashion. These effects were partially blocked by naloxane. On L-type calcium currents, morphine sh owed no effect. However, methadone inhibited the L-calcium currents in dose -dependent fashion. This effect was not antagonised by naloxone. Hence, the action of methadone on L-calcium channel is probably not associated with m u receptors. (C) 2000 Elsevier Science B.V. All rights reserved.