Immediate-early gene expression in cerebral cortex following exposure to chronic-intermittent hypoxia

Authors
Sica, AL Greenberg, HE Scharf, SM Ruggiero, DA
Citation
Al. Sica et al., Immediate-early gene expression in cerebral cortex following exposure to chronic-intermittent hypoxia, BRAIN RES, 870(1-2), 2000, pp. 204-210
Citations number
29
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
870
Issue
1-2
Year of publication
2000
Pages
204 - 210
Database
ISI
SICI code
0006-8993(20000707)870:1-2<204:IGEICC>2.0.ZU;2-U
Abstract
Chronic-intermittent hypoxia (CIH) was postulated to evoke c-fos expression in cortical regions that modulate sympathetic discharge. Animals exposed t o CIH for 30 days exhibited c-fos labeling in medial prefrontal, cingulate. retrosplenial, and insular cortices. Our findings strongly suggest activat ion of cortical circuits that adaptively regulate sympathetic and cardiovas cular activities. (C) 2000 Elsevier Science B.V. All rights reserved.