A novel class of cationic gemini surfactants showing efficient in vitro gene transfection properties

Authors
Camilleri, P Kremer, A Jennings, KH Jenkins, O Marshall, I McGregor, C Neville, W Rice, SQ Smith, RJ Wilkinson, MJ Kirby, AJ
Citation
P. Camilleri et al., A novel class of cationic gemini surfactants showing efficient in vitro gene transfection properties, CHEM COMMUN, (14), 2000, pp. 1253-1254
Citations number
7
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
14
Year of publication
2000
Pages
1253 - 1254
Database
ISI
SICI code
1359-7345(2000):14<1253:ANCOCG>2.0.ZU;2-F
Abstract
Five novel peptide-based cationic gemini surfactants have been synthesised and their ability to transfect plasmid DNA containing the luciferase gene h as been examined. Three of these detergents, differing in the number of pos itive charges per molecule at neutral pH, mediated transfection on their ow n. However, their efficiency increased markedly on the addition of a neutra l colipid and a basic polypeptide.