Cytopathological observations on renal tubule epithelium cells in common carp Cyprinus carpio under Trypanoplasma borreli (Protozoa : Kinetoplastida)infection
S. Rudat et al., Cytopathological observations on renal tubule epithelium cells in common carp Cyprinus carpio under Trypanoplasma borreli (Protozoa : Kinetoplastida)infection, DIS AQU ORG, 40(3), 2000, pp. 203-209
Cytological alterations in renal tubule epithelium cells of carp Cyprinus c
arpio infected with the blood flagellate Trypanoplasma borreli Laveran & Me
snil, 1901 were investigated during the course of a laboratory infection of
a highly susceptible carp line. With the development of the parasitaemia,
a hyperplasia of the interstitial renal tissue was induced, which resulted
in a tubulus necrosis. Cytological changes were already seen in tubulus epi
thelium cells on Day 7 post injection (PI) of the parasite. The basilar inv
aginations of the cells fragmented and a swelling of mitochondria was noted
. With increasing parasitaemia, on Days 14 and 21 PI, these changes progres
sed up to the loss of the basilar invagination and high amplitude swellings
of mitochondria and deterioration of their internal membrane structures. C
ells of the distal tubule segment reacted earlier and more rapidly than cel
ls of the proximal tubule. The cytological alterations suggested a loss of
function of the epithelum cells, which most likely resulted in impaired ion
ic and osmotic regulation of T. borreli-infected fishes. Our findings indic
ate that in response to the proliferation of the interstitial renal tissue
cell structures of the renal tubule cells are altered quickly and in a prog
ressive manner.