Formulation of activated charcoal for Per Os administration to addicted subjects

The objective of this work was to develop a galenic form of activated charc oal appropriate for the needs of clinical toxicology. To preserve the adsor ption capacity of charcoal, we developed an extemporaneous preparation of a ctivated charcoal intended for clinical toxicology. To improve the wettabil ity of activated charcoal, we used densification by wet granulation. The pr esence of a viscosity agent is necessary to ensure the homogeneity of the s uspension and its adhesiveness on gastric mucous membrane. Five formulation s with different viscosity agents were prepared, and their adsorption capac ity, wettability, viscosity and adhesiveness were studied.