Studies of ion-exchange resin complex of chloroquine phosphate

Authors
Agarwal, R Mittal, R Singh, A
Citation
R. Agarwal et al., Studies of ion-exchange resin complex of chloroquine phosphate, DRUG DEV IN, 26(7), 2000, pp. 773-776
Citations number
13
Categorie Soggetti
Pharmacology & Toxicology
Journal title
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
ISSN journal
03639045 → ACNP
Volume
26
Issue
7
Year of publication
2000
Pages
773 - 776
Database
ISI
SICI code
0363-9045(2000)26:7<773:SOIRCO>2.0.ZU;2-W
Abstract
High-potency adsorbates of chloroquine phosphate (CQP) were prepared by the batch method using a polyacrylic acid ion-exchange resin. Taste evaluation of the adsorbates shows significant masking of the bitterness of the drug. The complex formation was complete at pH 6.0. Stability studies at 37 degr ees C, 45 degrees C,and 60 degrees C indicated that the complex was stable at all conditions for 1 month. In vitro release studies revealed complete d rug elution from the complex at pH 1.2 and 2.0.