SYNTHESIS OF )-3-PROPARGYL-5-ETHYL-6-METHYL-4(3H)-PYRIMIDINONE, A PROMISING NEW HERBICIDE

Authors
TAYLOR EC ZHOU P TICE CM LIDERT Z ROEMMELE RC
Citation
Ec. Taylor et al., SYNTHESIS OF )-3-PROPARGYL-5-ETHYL-6-METHYL-4(3H)-PYRIMIDINONE, A PROMISING NEW HERBICIDE, Tetrahedron letters, 38(25), 1997, pp. 4339-4342
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
25
Year of publication
1997
Pages
4339 - 4342
Database
ISI
SICI code
0040-4039(1997)38:25<4339:SO)AP>2.0.ZU;2-X
Abstract
A novel synthesis of the promising new herbicide chloro-4-pyridyl)-3-p ropargyl-5-ethyl-6-methyl-4(3 (H) under bar)-pyrimidinone (12) is repo rted which features (1) regioselective carbon, followed by nitrogen, d ialkylation of art intermediate dianion, and (2) a tandem ''one-pot'' sequence of reactions involving sigmatropic sulfoxide elimination, lit hium chloride-induced demethylation of a carbomethoxy grouping, decarb oxylation, and isomerization/aromatization. (C) 1997 Elsevier Science Ltd.