SYNTHESIS OF A DINUCLEATING LIGAND WITH ADDRESSED ION-BINDING SITES

A ligand was synthesized that contains two binding sites, differentiat ed on the basis of size and donor atom. The binding profile for a seri es of amino acid guests suggest that the two binding sites are 6.5 Ang strom apart. Kinetic studies of hydrolysis of a model phosphodiester s ubstrate by heterodinuclear complexes of the ligand suggest that one m etal ion delivers a hydroxide nucleophile and the other increases subs trate binding although not in the ideal geometry. (C) 1997 Elsevier Sc ience Ltd.