A 2-STEP SYNTHESIS OF NEW MACROBICYCLIC AZA-LIGANDS STARTING FROM TRANSDIOXOCYCLAM AS DIPROTECTED MACROCYCLE

Authors
DENAT F LACOUR S BRANDES S GUILARD R
Citation
F. Denat et al., A 2-STEP SYNTHESIS OF NEW MACROBICYCLIC AZA-LIGANDS STARTING FROM TRANSDIOXOCYCLAM AS DIPROTECTED MACROCYCLE, Tetrahedron letters, 38(25), 1997, pp. 4417-4420
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
25
Year of publication
1997
Pages
4417 - 4420
Database
ISI
SICI code
0040-4039(1997)38:25<4417:A2SONM>2.0.ZU;2-2
Abstract
A rapid and convenient synthesis of two small aza-cryptands containing a 1,4,8,11-tetraazacyclotetradecane backbone is reported. This strate gy can be applied to the preparation of many other aza-cages by varyin g the nature of the cross linker. Moreover, the two remaining secondar y amine sites may allow the functionalization of these ligands or thei r grafting on a polymer. (C) 1997 Published by Elsevier Science Ltd.