The axial organ of sea star Asterias rubens is a primitive immune organ whi
ch in certain conditions produces an antibody-like factor (ALF). This A.L.F
. presents homologies with the human Ic chain. The ALF could be composed of
many kappa chains devoid of any disulfide bond. The ontogeny of K expressi
on was studied. Just after metamorphosis of the sea star, certain mesodermi
c cells which become axial organ cells express human kappa-like activity.