The geographic distribution of cystic fibrosis mutations gives clues aboutpopulation origins

Information regarding three of the more common cystic fibrosis mutations is presented (Delta F508, G542X, N13031K) to support the concept of a geograp hy associated with cystic fibrosis mutations. We present the hypothesis tha t a knowledge of the geography of cystic fibrosis mutations is important fo r an understanding of genotype-phenotype correlations, gene flow, historica l population migration and cystic fibrosis screening. Conclusion A new method of study of mankind's cultural spread is being reve aled and the survival of the various mutations supports the concept that th ey may provide a selective advantage to the carrier.