S. Kawakami et al., Central administration of alpha-melanocyte stimulating hormone inhibits fasting- and neuropeptide Y-induced feeding in neonatal chicks, EUR J PHARM, 398(3), 2000, pp. 361-364
In the present study, the effect of intracerebroventricular (i.c.v.) admini
stration of alpha-melanocyte stimulating hormone (alpha-MSH) on food intake
of neonatal chicks was examined. In experiment 1, i.c.v. injection of alph
a-MSH (0.04, 0.2 and 1 mu g) significantly inhibited food intake of 3-h fas
ted chicks in a dose-dependent manner. In experiment 2, alpha-MSH strongly
inhibited neuropeptide Y-induced feeding when neuropeptide Y (2.5 mu g) and
several doses of alpha-MSH were given simultaneously i.c.v. These results
suggest that alpha-MSH plays an important role in the regulation of food in
take of neonatal chicks. (C) 2000 Elsevier Science B.V. All rights reserved
.