DYNAMIC PROPERTIES OF THE AORTA AND OF THE FOOT MICROCIRCULATION IN ADOLESCENTS WITH DIABETES-MELLITUS

Citation
J. Hu et al., DYNAMIC PROPERTIES OF THE AORTA AND OF THE FOOT MICROCIRCULATION IN ADOLESCENTS WITH DIABETES-MELLITUS, Acta paediatrica, 86(6), 1997, pp. 620-625
Citations number
38
Categorie Soggetti
Pediatrics
Journal title
ISSN journal
08035253
Volume
86
Issue
6
Year of publication
1997
Pages
620 - 625
Database
ISI
SICI code
0803-5253(1997)86:6<620:DPOTAA>2.0.ZU;2-M
Abstract
To evaluate vascular function in diabetic subjects, we studied both th e stiffness of the abdominal aorta and the fool microvascular reactivi ty in 22 diabetic adolescents and 18 controls. The aortic stiffness wa s significantly higher in diabetic females, but not in males, as compa red to age- and gender-matched controls (p < 0.05), Foot post-ischaemi c hyperaemia was lower in diabetic subjects: than in controls (p < 0.0 5), while postural vasoconstriction did not differ between the groups. The microvascular reactivity did not correlate with the duration of d iabetes, but seemed to be influenced by the insulin regimen. The degre e of aortic stiffness and the microvascular reactivity of the foot wer e not significantly interrelated. Loss of aortic elasticity might be a long-term effect of diabetes, whereas microvascular reactivity seems to reflect the current influence of the metabolic state and insulin tr eatment.