Jm. Van Montfrans et al., Predictive value of basal follicle-stimulating hormone concentrations in ageneral subfertility population, FERT STERIL, 74(1), 2000, pp. 97-103
Objective: To assess the predictive value of elevated basal FSH concentrati
ons during the initial subfertility workup with respect to fecundity in a g
eneral subfertility population with ovulatory menstrual cycles.
Design: Nested case-control study.
Setting: Fertility center of a university hospital.
Patient(s): Fifty subfertile women with basal FSH levels >10.0 IU/L and 50
age-matched controls.
Intervention(s): Long-term follow-up (3-7 years).
Main Outcome Measure(s): Pregnancies, deliveries, and time to pregnancy.
Result(s): Patients with elevated basal FSH levels and controls were compar
able with regard to basic characteristics, clinical diagnoses, and subferti
lity treatment. Long-term follow-up showed that 52% of the women with eleva
ted basal FSH concentrations became pregnant (positive predictive value 48%
) versus 62% of the controls, and 42% versus 46% eventually delivered a chi
ld, respectively. The mean time to pregnancy was 3.0 years in the elevated-
FSH group and 3.4 years in controls. Most of the pregnancies in both groups
occurred after spontaneous conceptions.
Conclusion(s): The results of this study suggest that screening for elevate
d basal FSH concentrations is of no additional value in a general subfertil
ity population with ovulatory menstrual cycles. (Fertil Steril(R) 2000;74:
97-103. (C) 2000 by American Society for Reproductive Medicine.)