GERM-CELL TUMORS IN A BROTHER AND SISTER

In familial germ cell tumour cases, a normal chromosomal karyotype pat tern is rare. We report the findings of germ cell rumours in two sibli ngs with a normal chromosomal karyotype. One of these patients had dys germinoma in the right ovary and was treated successfully for this. At present, she is 23 years old and has two daughters, The other patient is a 15-year-old boy, who is the brother of the first patient and has mediastinal embryonal carcinoma. Although ultrasonography of the test es showed irregularity in the shape and non-homogeneity of the parench yma, histopathological examination was found to be normal at the time of diagnosis, At present, he is doing well and his. chemotherapy is co ntinuing. Both of them have a normal chromosomal karyotype, 46,XX and 46,XY, respectively. We suggest that children who have a sibling with germ fell tumour should be carefully assessed for development of anoth er germ cell tumour.