REGULATION OF CDK CYCLIN COMPLEXES DURING THE CELL-CYCLE/

The eukaryotic cell cycle is regulated by the temporal activation of d ifferent cyclin-dependent kinase (CDK)/cyclin complexes. Whilst the le vel of the catalytic subunit of the complex, the CDK, remains relative ly constant through the cycle, the level of the cyclin subunit general ly oscillates. Cyclins are synthesized, bind and activate the CDK and are then destroyed. Tn this review, we summarize the current knowledge of the regulation of the cell cycle by CDK/cyclin complexes with spec ial emphasis on new developments in cyclin biosynthesis and destructio n, the structural analysis of the CDK/cyclin complexes and the role of a set of inhibitors of CDK/cyclin complexes that are important for th e coordination of the different stages of the fell cycle. (C) 1997 Pub lished by Elsevier Science Ltd.