Investigation of minimal residual disease in adult Ph1 positive acute lymphoblastic leukemia by a combination of cell sorting and fluorescence in situ hybridization: a preliminary study on 6 cases

Authors
Cambier, N Soenen-Cornu, V Lai, JL Cosson, A Fenaux, P Preudhomme, C
Citation
N. Cambier et al., Investigation of minimal residual disease in adult Ph1 positive acute lymphoblastic leukemia by a combination of cell sorting and fluorescence in situ hybridization: a preliminary study on 6 cases, HAEMATOLOG, 85(6), 2000, pp. 664-665
Citations number
9
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
HAEMATOLOGICA
ISSN journal
03906078 → ACNP
Volume
85
Issue
6
Year of publication
2000
Pages
664 - 665
Database
ISI
SICI code
0390-6078(200006)85:6<664:IOMRDI>2.0.ZU;2-R
Abstract
We studied minimal residual disease in 6 patients with Philadelphia positiv e acute lymphoblastic leukemia(Phl ALL) in remission by using a combination of cell sorting (CD34(+)) and FISH. The detection of residual leukemic cel ls in Phl ALL by using this method is much more sensitive than conventional morphology and cytogenetic analyses.