Transformation of severe aplastic anemia into myelodysplastic syndrome with monosomy 7: monoclonal origin detected by HUMARA gene analysis during theaplastic anemia phase

Authors
Sashida, G Tauchi, T Katagiri, T Kuriya, S Ohyashiki, K
Citation
G. Sashida et al., Transformation of severe aplastic anemia into myelodysplastic syndrome with monosomy 7: monoclonal origin detected by HUMARA gene analysis during theaplastic anemia phase, HAEMATOLOG, 85(6), 2000, pp. 665-666
Citations number
5
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
HAEMATOLOGICA
ISSN journal
03906078 → ACNP
Volume
85
Issue
6
Year of publication
2000
Pages
665 - 666
Database
ISI
SICI code
0390-6078(200006)85:6<665:TOSAAI>2.0.ZU;2-Q
Abstract
A patient with aplastic anemia showed a monoclonal pattern on the HUMARA ge ne before the development of a myelodysplastic syndrome (MDS). The present case strongly suggests that if patients with aplastic anemia reveal monoclo nality of the HUMARA gene, they should be considered to have a borderline d isorder between aplastic anemia and MDS.