Cytotoxic lymphomas

Cytotoxic lymphomas are peripheral T- and natural killer-cell lymphomas wit h primary or secondary skin manifestations. They constitute a heterogenous group of lymphoproliferative disease. They are characterized by expression of cytotoxic proteins and are frequently associated with an aggressive clin ical course. A brief introduction to cytotoxic lymphocytes and proteins is followed by a detailed description of clinical, histological, immunohistoch emical and genetic characteristics of cutaneous cytotoxic lymophomas.