Complete remission of the liver metastases of anorectal malignant melanomawith regional chemotherapy: A case report

The prognosis of anorectal malignant melanoma is very poor. We present a 48 -year-old male patient with anorectal malignant melanoma and multiple liver metastases who underwent abdominoperineal resection. A port system was imp lanted to the gastroduodenal artery for regional chemotherapy for liver met astases. Histopathological findings of tumor were 5 cm diameter and 2 cm de pth, invading Abdominoperineal to the external sphincter. Both regional che motherapy and immunotherapy were initiated 4 weeks postoperatively. The imm unochemotherapy regimen included cisplatin (via port system) 50 mg/m(2) onc e in 2 weeks, x 8 cycles, a-interferon 5 x 10(6)U subcuteneously on days 1- 7 in 4 weeks, x 8 cycles, interleukin-2 9 x 10(6)U subcuteneously on days 5 -9 in 4 weeks, x 8 cycles. Computed tomography scan was taken after the 2nd and 4th cycles of chemotherapy and the tumor had not responded to chemothe rapy. Dacarbazine 200 mg/m(2) intravenously on days 1-5 in a month, x 4 cyc les, was added to the previous immunochemotherapy regimen. Computed tomogra phy and magnetic resonance imaging scans were taken on the 10th and 12th mo nths after operation, respectively, no evidence of metastases in the liver was noted. No case of complete remission of liver metastases of anorectal m alignant melanoma with regional intraarterial chemotherapy and systemic imm unochemotherapy has been previously reported in the literature.