A facile method for regioselective 6,7-disubstitution of pteridine

Authors
Murata, S Seo, C Kujime, M Sugimoto, T
Citation
S. Murata et al., A facile method for regioselective 6,7-disubstitution of pteridine, HETEROCYCLE, 53(6), 2000, pp. 1259-1262
Citations number
13
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
53
Issue
6
Year of publication
2000
Pages
1259 - 1262
Database
ISI
SICI code
0385-5414(20000601)53:6<1259:AFMFR6>2.0.ZU;2-J
Abstract
Substitution of 1,3-dimethyl-2,4(1H,3H)-pteridinedione 6-triflate by copper acetylide proceeds regioselectively on the 7-position to give correspondin g 7-alkynylpteridine 6-triflate whose triflate group can be subsequently re placed by various nucleophiles.