Possible relationships between plasma carbamazepine-10,11-epoxide levels and antimanic efficacy and side effects in patients with schizoaffective disorder

Authors
Yoshimura, R Nakamura, J Eto, S Ueda, N
Citation
R. Yoshimura et al., Possible relationships between plasma carbamazepine-10,11-epoxide levels and antimanic efficacy and side effects in patients with schizoaffective disorder, HUM PSYCHOP, 15(4), 2000, pp. 237-240
Citations number
14
Categorie Soggetti
Neurosciences & Behavoir
Journal title
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
ISSN journal
08856222 → ACNP
Volume
15
Issue
4
Year of publication
2000
Pages
237 - 240
Database
ISI
SICI code
0885-6222(200006)15:4<237:PRBPCL>2.0.ZU;2-6
Abstract
We examined the relationships of plasma levels of carbamazepine (CBZ) and i ts two major metabolites, carbamazepine-10,11-epoxide (CBZ-E) and carbamaze pine-10,11-diol (CBZ-D), with antimanic efficacy and side effects in patien ts with schizoaffective disorder. Positive relationships were found among p lasma concentrations of CBZ-E and the degree of clinical improvement and si de effects, whereas neither plasma CBZ nor CBZ-D levels were correlated wit h the degree of clinical improvement or side effects. Copyright (C) 2000 Jo hn Wiley & Sons, Ltd.