The human and mouse MHC class III region: a parade of 21 genes at the centromeric segment

Authors
Yu, CY Yang, ZY Blanchong, CA Miller, W
Citation
Cy. Yu et al., The human and mouse MHC class III region: a parade of 21 genes at the centromeric segment, IMMUNOL TOD, 21(7), 2000, pp. 320-328
Citations number
67
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
21
Issue
7
Year of publication
2000
Pages
320 - 328
Database
ISI
SICI code
0167-5699(200007)21:7<320:THAMMC>2.0.ZU;2-E
Abstract
The human major histocompatibility complex (MHC) class III region contains 57-60 structural genes spanning 654-759 kb of genomic DNA. Analysis of the sequence identities of the human and mouse genomic regions between NOTCH4 a nd complement C2 yields important information on the locations of the codin g and regulatory sequences. I also provides insights into the relationship between protein function and level of sequence conservation, and on the clu stering of genes with related functions.