Co-stimulation and selection for T-cell help for germinal centres: The role of CD28 and OX40

Authors
Walker, LSK Gulbranson-Judge, A Flynn, S Brocker, T Lane, PJL
Citation
Lsk. Walker et al., Co-stimulation and selection for T-cell help for germinal centres: The role of CD28 and OX40, IMMUNOL TOD, 21(7), 2000, pp. 333-337
Citations number
35
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
21
Issue
7
Year of publication
2000
Pages
333 - 337
Database
ISI
SICI code
0167-5699(200007)21:7<333:CASFTH>2.0.ZU;2-R
Abstract
Given the importance of responding to infections with the right defensive s trategy, much interest has focused on cytokine differentiation in CD4(+) T cells. However, relatively little is known of the logistics of T-cell help for B cells. Here, Lucy Walker and colleagues propose key roles for CD28 an d OX40 in coordinating the selection, expansion and migration of CD4(+) T c ells to B-cell follicles.