IFN-alpha and IFN-beta: A link between immune memory and chronic inflammation

Authors
Akbar, AN Lord, JM Salmon, M
Citation
An. Akbar et al., IFN-alpha and IFN-beta: A link between immune memory and chronic inflammation, IMMUNOL TOD, 21(7), 2000, pp. 337
Citations number
39
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
21
Issue
7
Year of publication
2000
Database
ISI
SICI code
0167-5699(200007)21:7<337:IAIALB>2.0.ZU;2-V
Abstract
The majority of expanded T cells generated during an immune response are cl eaned by apoptosis. Prevention of death in some activated T cells enables t he persistence of a memory T-cell pool. Here, observations that IFN-alpha a nd IFN-beta inhibit activated T-cell apoptosis are described. Although this enables memory T cells to persist without antigen, excessive IFN-alpha ol IFN-gamma secretion might lead to chronic inflammation.