The causative H+/K+ ATPase antigen in the pathogenesis of autoimmune gastritis

Authors
Toh, BH Sentry, JW Alderuccio, F
Citation
Bh. Toh et al., The causative H+/K+ ATPase antigen in the pathogenesis of autoimmune gastritis, IMMUNOL TOD, 21(7), 2000, pp. 348
Citations number
50
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
21
Issue
7
Year of publication
2000
Database
ISI
SICI code
0167-5699(200007)21:7<348:TCHAAI>2.0.ZU;2-1
Abstract
The gastric H+/K+ ATPase is the causative autoantigen recognised by CD4(+) T cells that mediate autoimmune gastritis. Pathogenic CD4(+) T cells are re gulated by CD25(+)CD4(+) T cells. Here, it is proposed that waves of activa tion and migration of antigen presenting cells and CD4(+) T cells to and fr om the target organ and draining lymph node result in tissue damage.