Sc. Goodwin et al., Percutaneous delivery of a heparin-impregnated collagen stent-graft in a porcine model of atherosclerotic disease, INV RADIOL, 35(7), 2000, pp. 420-425
Citations number
28
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
RATIONALE AND OBJECTIVES. TO develop collagen stent-grafts impregnated with
heparin to improve the biocompatibility of endovascular stents and to desi
gn a percutaneous delivery system for graft deployment in a swine model.
METHODS. Heparin-impregnated collagen stent-grafts were deployed, and follo
w-up angiograms were obtained every 15 minutes for 90 minutes to assess acu
te thromboses and again at 2 and 4 weeks afterward to assess patency, If st
enosis or occlusion was detected at the 2-week evaluation, guidewire passag
e across the lesion was attempted and angioplasty was performed. If stenosi
s or occlusion was present at the 4-week evaluation, only guidewire passage
was attempted; thereafter, the animals were killed and the stent-grafts we
re harvested and reviewed by a vascular pathologist.
RESULTS. Group A represents a feasibility study to optimize the deployment
method applied in groups B and C. Fifteen of 17 stent-grafts were successfu
lly deployed using this method. In group B, 89% of grafts were successfully
deployed; 12% were patent at 2 weeks and none at 4 weeks. In group C, a 10
-minute inflation time was added to the deployment procedure; 88% of grafts
were successfully deployed and 28% were patent at 2 weeks and 14% at 4 wee
ks. Extensive luminal thrombosis and myointimal hyperplasia were present in
every case.
CONCLUSIONS. A method was developed for percutaneous implantation of collag
en stent-grafts into peripheral vessels. The heparin-impregnated grafts did
not prevent vessel restenosis, Modification of the graft-processing techni
que may improve patency.