Percutaneous delivery of a heparin-impregnated collagen stent-graft in a porcine model of atherosclerotic disease

Citation
Sc. Goodwin et al., Percutaneous delivery of a heparin-impregnated collagen stent-graft in a porcine model of atherosclerotic disease, INV RADIOL, 35(7), 2000, pp. 420-425
Citations number
28
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
Journal title
INVESTIGATIVE RADIOLOGY
ISSN journal
00209996 → ACNP
Volume
35
Issue
7
Year of publication
2000
Pages
420 - 425
Database
ISI
SICI code
0020-9996(200007)35:7<420:PDOAHC>2.0.ZU;2-S
Abstract
RATIONALE AND OBJECTIVES. TO develop collagen stent-grafts impregnated with heparin to improve the biocompatibility of endovascular stents and to desi gn a percutaneous delivery system for graft deployment in a swine model. METHODS. Heparin-impregnated collagen stent-grafts were deployed, and follo w-up angiograms were obtained every 15 minutes for 90 minutes to assess acu te thromboses and again at 2 and 4 weeks afterward to assess patency, If st enosis or occlusion was detected at the 2-week evaluation, guidewire passag e across the lesion was attempted and angioplasty was performed. If stenosi s or occlusion was present at the 4-week evaluation, only guidewire passage was attempted; thereafter, the animals were killed and the stent-grafts we re harvested and reviewed by a vascular pathologist. RESULTS. Group A represents a feasibility study to optimize the deployment method applied in groups B and C. Fifteen of 17 stent-grafts were successfu lly deployed using this method. In group B, 89% of grafts were successfully deployed; 12% were patent at 2 weeks and none at 4 weeks. In group C, a 10 -minute inflation time was added to the deployment procedure; 88% of grafts were successfully deployed and 28% were patent at 2 weeks and 14% at 4 wee ks. Extensive luminal thrombosis and myointimal hyperplasia were present in every case. CONCLUSIONS. A method was developed for percutaneous implantation of collag en stent-grafts into peripheral vessels. The heparin-impregnated grafts did not prevent vessel restenosis, Modification of the graft-processing techni que may improve patency.