Epidermal growth factor receptor signal transactivation

Cross-communication between heterologous signaling systems and the epiderma l growth factor receptor (EGFR) has been shown to be critical for a variety of biological responses: EGFR transactivation when G-protein-coupled recep tors (GPCRs) are stimulated represents the paradigm of an interreceptor net work that is dependent on G-proteins, kinases, metalloproteases, and growth factor precursors. Investigating the mechanism of this process will help e xpand our knowledge of physiological regulatory mechanisms and diverse path ophysiological disorders.