Mw. Ziegenhagen et al., Serum level of soluble tumour necrosis factor receptor II (75 kDa) indicates inflammatory activity of sarcoidosis, J INTERN M, 248(1), 2000, pp. 33-41
Citations number
36
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Objectives. Tumour necrosis factor alpha (TNF alpha) is a key cytokine invo
lved in granuloma formation of sarcoidosis. Since soluble TNF receptors (sT
NF-R) are known to inhibit TNF effects, we were interested in whether they
are elevated in the serum of sarcoidosis patients.
Methods. We determined serum levels of sTNF-R I (55 kDa) and sTNF-R II (75
kDa) in 49 patients with sarcoidosis and 22 controls. The clinical course o
f the disease was re-evaluated in a follow-up after (mean +/- SE) 6.8 +/- 6
.6 months.
Results. sTNF-R I (3.1 +/- 1.1 ng mL(-1), P < 0.05) and sTNF-R II (5.5 +/-
2.7 ng mL(-1), P < 0.0005) were significantly elevated in sarcoidosis compa
red with controls (2.4 +/- 0.7 and 3.0 +/- 1.3 ng mL(-1), respectively). In
terestingly, both sTNF receptors were significantly higher in the serum of
patients with active compared with inactive sarcoidosis (P < 0.005 and P <
0.0005, respectively). Furthermore, serum sTNF-R II levels were significant
ly higher in sarcoidosis patients with advanced radiological types II and I
II. In 10 patients, serum sTNF-R levels were obtained before and after syst
emic corticosteroid therapy and we observed a significant decrease of sTNF-
R II (P < 0.02), whereas sTNF-R I levels were not reduced significantly.
Conclusions. Both types of sTNF receptors are elevated in the serum of sarc
oidosis patients with active disease, but only the sTNF-R II seems to be us
eful for monitoring the inflammatory activity of the disease.