Lipoinsulin encapsulated alginate-chitosan capsules: intestinal delivery in diabetic rats

An oral formulation based on liposome encapsulated alginate-chitosan gel ca psules was developed for insulin delivery for the treatment of diabetes. Li posome encapsulation helped to increase the encapsulation efficiency of ins ulin in alginate-chitosan capsules. This formulation delivers insulin in th e neutral environment of the intestine, by-passing the acidic media in the stomach, with increased drug absorption and bioavailability. Oral administr ation of this formulation was found to reduce blood glucose levels when tes ted in diabetic rats.