In this study, liposomes containing glutathione were evaluated to detect in
fection in mice. Glutathione liposomes were labelled by using 99mTc-Iabelle
d-HMPAO (hexamethyl propylamine oxime). Mice were infected in the thigh by
intramuscular injection with turbentine. Labelled liposomes were applied to
the tail vein of the mice intravenously. At fixed time intervals they were
sacrificed. The animals were imaged under a gamma camera. Then, tissue sam
ples were excised and radioactivity of all organs was counted. Abscess-to-m
uscle, abscess-to-liver, and abscess-to-spleen ratios were calculated. The
ratios of abscess-to-muscle were found to be 1.6 and 11.6 at 1 h and 24 h,
respectively. According to these data, the abscess can be defined at Ih and
it became more clear with time.