New chiral ligands containing oxazoline unit and pyridine separated by a me
thylene group 3 have been synthesized from enantiomerically pure amino alco
hols and 2-picoline using a convenient procedure. Comparative investigation
of ligands 3 with chiral conjugate pyridinyl-oxazoline ligands 2 and quino
linyl-oxazoline ligands 1 in copper(I)-catalyzed asymmetric cyclopropanatio
n of styrene with diazoacetates was described. (C) 2000 Elsevier Science B.
V. All rights reserved.