A novel cyclodextrin homodimer with dual-mode substrate binding and esterase activity

Authors
Tastan, P Akkaya, EU
Citation
P. Tastan et Eu. Akkaya, A novel cyclodextrin homodimer with dual-mode substrate binding and esterase activity, J MOL CAT A, 157(1-2), 2000, pp. 261-263
Citations number
13
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
ISSN journal
13811169 → ACNP
Volume
157
Issue
1-2
Year of publication
2000
Pages
261 - 263
Database
ISI
SICI code
1381-1169(20000620)157:1-2<261:ANCHWD>2.0.ZU;2-K
Abstract
A novel cyclodextrin homodimer with two beta-cyclodextrin units tethered fr om the primary side by a tris(2-aminoethyl)amine linker was found to be hyd rolytically active. The hydrolysis of a ditopic activated carbonate ester w as accelerated 150-fold and a Lineweaver-Burk plot showed a biphasic curve indicative of two different binding modes for the activated carbonate ester . (C) 2000 Elsevier Science B.V. All rights reserved.