Ribofuranosyl triazolone: A natural product herbicide with activity on adenylosuccinate synthetase following phosphorylation

Authors
Schmitzer, PR Graupner, PR Chapin, EL Fields, SC Gilbert, JR Gray, JA Peacock, CL Gerwick, BC
Citation
Pr. Schmitzer et al., Ribofuranosyl triazolone: A natural product herbicide with activity on adenylosuccinate synthetase following phosphorylation, J NAT PROD, 63(6), 2000, pp. 777-781
Citations number
19
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
63
Issue
6
Year of publication
2000
Pages
777 - 781
Database
ISI
SICI code
0163-3864(200006)63:6<777:RTANPH>2.0.ZU;2-R
Abstract
2,4-Dihydro-4-(beta-D-ribofuranosyl)-1,2,4(3H)-triazol-3-one (2) was identi fied as the principal phytotoxic component of a fermentation broth derived from an Actinomadura. The compound is a new natural product, but known by s ynthesis. Broad-spectrum herbicidal activity was demonstrated in greenhouse tests. Metabolite reversal studies suggested the target site was adenylosu ccinate synthetase, which was confirmed by direct measurement of the activi ty of the 5'-phosphorylated derivative on the isolated enzyme.