New diterpenic altrosides of the fungus Acremonium striatisporum isolated from a sea cucumber

Two new diterpenic glycosides, virescenosides M (1) and N (2), have been is olated from a marine strain of Acremonium striatisporum KMM 4401 associated with the holothurian Eupentacta fraudatrix. Their structures were determin ed on the basis of MS and NMR data as beta-D-altropyranosido-19-7-oxo-isopi mara-8,15-diene-2 alpha,3 beta-diol (1) and beta-D-altropyranosido-19-isopi mara-7,15-diene-2 alpha,3 beta,6 beta-triol (2). Three other altrosides (3- 5), identified as virescenosides A, B, and C from the terrestrial strain Ac remonium luzulae, were also isolated. The cytotoxic activity of the viresce nosides was examined.