Injections of botulinum toxin A into the salivary glands improve sialorrhoea in amyotrophic lateral sclerosis

Authors
Giess, R Naumann, M Werner, E Riemann, R Beck, M Puls, I Reiners, C Toyka, KV
Citation
R. Giess et al., Injections of botulinum toxin A into the salivary glands improve sialorrhoea in amyotrophic lateral sclerosis, J NE NE PSY, 69(1), 2000, pp. 121-123
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
ISSN journal
00223050 → ACNP
Volume
69
Issue
1
Year of publication
2000
Pages
121 - 123
Database
ISI
SICI code
0022-3050(200007)69:1<121:IOBTAI>2.0.ZU;2-I
Abstract
Sialorrhoea is a socially disabling problem in bulbar amyotrophic lateral s clerosis (ALS). Botulinum toxin A (BoNT/A) was injected into the salivary g lands in five patients with bulbar ALS and sialorrhoea. The effect of BoNT/ A was measured by the number of paper handkerchiefs used each day and by sa livary gland scintigraphy. BoNT/A ameliorated sialorrhoea and quality of li fe without major adverse effects. BoNT/A may be a relatively safe and effec tive treatment for sialorrhoea in selected patients.