Fat embolism syndrome is a dire complication of long bone trauma. It is usu
ally associated with neurological, hematological and respiratory involvemen
t, the latter being the major cause of death. We present a case of severe f
at embolism syndrome occurring 3 hours after a long bone injury, leading to
permanent vegetative state and death without any respiratory signs. The di
agnosis was confirmed by cytology of the bronchoalveolar lavage fluid. Clin
ical presentation of the puzzling fat embolism syndrome and diagnostic test
s in suspected fat embolism syndrome are reviewed.