Effect of Bupropion-SR on orgasmic dysfunction in nondepressed subjects: Apilot study

The objective of this study was to determine whether the aminoketone antide pressant bupropion has beneficial effects in orgasmic dysfunction. Design: Single-blind, sequential treatment order of three weeks each: place bo, bupropion-SR 150 mg/day, bupropion-SR 300 mg/day. Subjects: Nondepressed women (n = 20) and men (n = 10) having nonphysiologi c orgasmic delay or inhibition Main Outcome Measure: reported difficulty or delay in achieving orgasm, sat isfaction with orgasm and erectile function, and subjective impressions of drug effect. Results: In the women, there were significant improvements relative to base line (p < .01) on both of bupropion-SR in all measured aspects of sexual fu nction, and significant improvements relative to placebo (p < .05) in overa ll sexual satisfaction on both doses and satisfaction with intensity of org asm on 150 mg/day (300 mg/day, p = .10). In the men, significant improvemen ts over baseline (p < .01) were observed with both doses in overall sexual satisfaction, ability to achieve an erection, and delay in reaching orgasm/ ejaculation; significant improvements relative to placebo (p < .05) were ob served in overall sexual satisfaction on both doses, ability to achieve ere ction on 150 mg/day, and delay in orgasm/ejaculation on 150 mg/day. Seventy percent of subjects reported improvement in libido, arousal, or orgasmic f unction during bupropion administration.