Voltage-gated potassium channels in human ductus arteriosus

Authors
Michelakis, E Rebeyka, I Bateson, J Olley, P Puttagunta, L Archer, S
Citation
E. Michelakis et al., Voltage-gated potassium channels in human ductus arteriosus, LANCET, 356(9224), 2000, pp. 134-137
Citations number
4
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
LANCET
ISSN journal
01406736 → ACNP
Volume
356
Issue
9224
Year of publication
2000
Pages
134 - 137
Database
ISI
SICI code
0140-6736(20000708)356:9224<134:VPCIHD>2.0.ZU;2-Q
Abstract
We studied tone in the human ductus arteriosus and show that the constricti on to oxygen is due to inhibition of voltage-gated potassium channels and, in the acute phase, is independent of endothelin-1.