Relief from glucose interference in microcin B17 biosynthesis by growth ina rotating-wall bioreactor

Authors
Fang, A Pierson, DL Mishra, SK Demain, AL
Citation
A. Fang et al., Relief from glucose interference in microcin B17 biosynthesis by growth ina rotating-wall bioreactor, LETT APPL M, 31(1), 2000, pp. 39-41
Citations number
8
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
LETTERS IN APPLIED MICROBIOLOGY
ISSN journal
02668254 → ACNP
Volume
31
Issue
1
Year of publication
2000
Pages
39 - 41
Database
ISI
SICI code
0266-8254(200007)31:1<39:RFGIIM>2.0.ZU;2-#
Abstract
Glucose interference in production of microcin B17 by Escherichia coli ZK65 0 was decreased sevenfold by growth in a ground-based rotating-wall bioreac tor operated in the simulated microgravity mode as compared with growth in flasks. When cells were grown in the bioreactor in the normal gravity mode, relief from glucose interference was even more dramatic, amounting to a de crease in glucose interference of over 100-fold.