H-1 NMRD profiles of diamagnetic proteins: a model-free analysis

A model-free analysis of the H-1 nuclear magnetic relaxation dispersion (NM RD) profiles of 14 proteins in aqueous solution was performed to reproduce the experimental dispersions, that are stretched with respect to Lorentzian s. The analysis, according to a recently proposed approach, shows a good co rrelation of all physically meaningful parameters with the molecular weight of the proteins, spanning the range from 6500 to 480 000, and, in particul ar, of the average correlation time with the Stokes-Einstein estimate of th e rotational correlation time. Copyright (C) 2000 John Wiley & Sons, Ltd.