Bsy. Li et al., H-1 decoupling for in vivo F-19 MRS studies using the time-share modulation method on a clinical 1.5 T NMR system, MAGN RES M, 44(1), 2000, pp. 5-9
Citations number
10
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
Time-share modulation has been implemented successfully on a clinical 1.5 T
nuclear magnetic resonance (NMR) system to perform in vivo F-19[-H-1] deco
upling, It uses commercially available radiofrequency (RF) filters, a trans
istor-transistor logic (TTL)-controlled attenuator, and a double-resonant R
F surface coil suitable for F-19 magnetic resonance spectroscopy (MRS) stud
ies in vivo. This decoupling scheme gives a threefold improvement in signal
-to-noise ratio performance compared with the conventional WALTZ-4 decoupli
ng scheme, when significant interaction exists between the decoupler and th
e receiver. It can also eliminate receiver saturation (i.e., saturation due
to coupling of the strong proton decoupling pulse to the F-19 coil) withou
t the need for a high-isolation coil system, thus allowing flexibility in c
oil geometry. This method has been demonstrated in vivo in patients receivi
ng B-fluorouracil chemotherapy. (C) 2000 Wiley-Liss, Inc.