Ion-pair formation in pharmaceutical analysis. Conductimetric determination of promazine, chlorpromazine, promethazine, imipramine and ciprofloxacin hydrochlorides in pure form, drug formulations and urine
Ym. Issa et al., Ion-pair formation in pharmaceutical analysis. Conductimetric determination of promazine, chlorpromazine, promethazine, imipramine and ciprofloxacin hydrochlorides in pure form, drug formulations and urine, MIKROCH ACT, 134(1-2), 2000, pp. 9-14
Potassium ferricyanide and sodium tetraphenylborate were used as titrants f
or the conductimetric determination of promazine HCl, chlorpromazine HCl, p
romethazine HCl, imipramine HCl and ciprofloxacin HCl through ion-associate
complex formation. The molar combining ratio, effects of dilution of titra
nt, temperature and solvent were studied. The accuracy of the method is ind
icated by excellent recovery (99.50-99.96%). The sensitivity of the propose
d method is discussed and the results are compared with the pharmacopoeial
or the official methods. The suggested method has been applied for the anal
ysis of the mentioned compounds in their pharmaceutical formulations and ur
ine.