Synthesis of sultam derivatives with expected biological activity. 15

4-(Trihydro-2H-1,2-thiazole-1,1-dioxide-2-yl)benzophenone (1), 4-(3,5-dimet hyl-1',2'-thiazine-1',1'-dioxide-2-yl)benzophenone (2), and 4-aetrahydro-2H -1,2-thiazine-1,1-dioxide-2-yl)benzophenone (6) were obtained from 4-aminob enzophenone and the appropriate reagents. Isomeric (E-) and (Z-) 2-Ethoxyca rbonyl-4-phenyl-4-(4-tetrahydro-1,2-thiazine-1,1-dioxide-2-yl)phenyl-3-bute noic acids (11 and 12) and 2-carboxy-4(N-phenylthiocarbamoyl)-1-phenyl-6-(t etrahydro-2H-1,2-thiazine-1,1-dioxide-2-yl)naphthalene (16) were also synth esized.