Reduction and preparation of a phthalimide derivative from a furo-heliangolide

Authors
da Silva, GVJ Heleno, VCG Constantino, MG
Citation
Gvj. Da Silva et al., Reduction and preparation of a phthalimide derivative from a furo-heliangolide, MOLECULES, 5(6), 2000, pp. 908-915
Citations number
11
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
MOLECULES
ISSN journal
14203049 → ACNP
Volume
5
Issue
6
Year of publication
2000
Pages
908 - 915
Database
ISI
SICI code
1420-3049(2000)5:6<908:RAPOAP>2.0.ZU;2-6
Abstract
Goyazensolide, a biologically active natural product classified as a furohe liangolide, was transformed in a phthalimide derivative that showed an enha nced biological activity against Tripanosoma cruzi. The complex natural pro duct was also reduced with high stereoselectivity by hydrogen/Wilkinson's c atalyst; an epimer of this product was obtained in the reduction with hydro gen/Pd-C.